Rigorously Pursuing Excellence

Meharry Medical College’s Research and Innovation Enterprise

Meharry Medical College exists to improve the well-being of humankind and empower diverse underserved populations by advancing health equity through research, education, health services and policy leadership.

We are transforming research to align micro to macro scales of inquiry, prioritizing pre-clinical equity upstream to reduce health care disparities downstream. Our goal is to increase healthspan, not merely lifespan. The more ease and order we promote, the more disease and disorder we prevent.

Working in collaboration with federal, corporate and institutional partners, Meharry investigators explore the scientific, environmental and social factors disproportionately affecting the health of minority communities and those living in poverty.

Immersive community research – and our nearly 150-year heritage of healing – connects the laboratory to the bedside and equips faculty, staff and students with unmatched insight and impact. Investment in Meharry’s research and innovation enterprise pays a return on mission: to improve the well-being of humankind.

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Investment in Meharry’s research enterprise pays a return on mission: to improve the well-being of humankind.

The rapid endocytic uptake of fetuin-A by adherent tumor cells is mediated by Toll-like receptor 4 (TLR4)

Published in FEBS Open Bio, October 2020

Authors: Portia L. Thomas, Gladys Nangami, Tanu Rana, Adam Evans, Stephen D Williams, Dylan Crowell, Anil Shanker, Amos M. Sakwe, Josiah Ochieng

Fetuin-A is a serum glycoprotein synthesized and secreted into blood by the liver. It’s main physiological function is the inhibition of ectopic calcification. A number of studies have demonstrated that it is a multifunctional protein – endocytic uptake of fetuin-A by tumor cells resulting in rapid cellular adhesion and spreading has been reported.

Meharry’s Office for Research & Innovation Research Digest

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Rigorously Pursuing Excellence

Meharry Medical College’s Research and Innovation Enterprise

Investment in Meharry’s research enterprise pays a return on mission: to improve the well-being of humankind.

Featured Article

The rapid endocytic uptake of fetuin-A by adherent tumor cells is mediated by Toll-like receptor 4 (TLR4)

Meharry’s Office for Research & Innovation Research Digest