Faculty Biography

Amos Sakwe, PhD, MSCI

Associate Professor
Secondary Appointment
Biochemistry, Cancer Biology, Neuroscience, Pharmacology
School of Graduate Studies and Research
(615) 327-6064 | asakwe@mmc.edu | Biosketch

Center Affiliations

Center for Women’s Health Research

Research Themes

Cancer Biology

Active Research Projects

Mechanisms of Annexin A6 mediated basal-like breast cancer progression, NIH/NIGMS 1SC1211030

Goals Schematic

A6 and GRF2-1


The rapid endocytic uptake of fetuin-A by adherent tumor cells is mediated by Toll-like receptor 4 (TLR4).
Thomas PL, Nangami G, Rana T, Evans A, Williams SD, Crowell D, Shanker A, Sakwe AM, Ochieng J

Diverse Roles of Annexin A6 in Triple-Negative Breast Cancer Diagnosis, Prognosis and EGFR-Targeted Therapies.
Korolkova OY, Widatalla SE, Williams SD, Whalen DS, Beasley HK, Ochieng J, Grewal T, Sakwe AM

Reciprocal expression of Annexin A6 and RasGRF2 discriminates rapidly growing from invasive triple negative breast cancer subsets.
Korolkova OY, Widatalla SE, Whalen DS, Nangami GN, Abimbola A, Williams SD, Beasley HK, Reisenbichler E, Washington MK, Ochieng J, Mayer IA, Lehmann BD, Sakwe AM

Implication of calcium activated RasGRF2 in Annexin A6-mediated breast tumor cell growth and motility.
Whalen DS, Widatalla SE, Korolkova OY, Nangami GS, Beasley HK, Williams SD, Virgous C, Lehmann BD, Ochieng J, Sakwe AM

Extracellular histones are the ligands for the uptake of exosomes and hydroxyapatite-nanoparticles by tumor cells via syndecan-4.
Ochieng J, Nangami G, Sakwe A, Rana T, Ingram S, Goodwin JS, Moye C, Lammers P, Adunyah SE


Triple negative breast cancer, tumor progression, cancer induced hypercalcemia, drug resistance, extracellular vesicles