1. Molecular circuitry underlying T-NK cell crosstalk (NIH 2SC1 CA182843)
2. Role of Fus1-mediated antitumor CD8T-NK crosstalk in Alzheimer’s disease pathology (3SC1 CA182843-07S1)
3. Development of immunotherapeutic agents, bioengineered Notch ligand constructs and sustained-release immune checkpoint ligands for cancer immunotherapy (NIH 2SC1 CA182843, 5U54 CA163069, 1R01 CA175370)
4. Building a prognostic Notch-based immunoscore signature for cancer health disparities (5U54 CA163069, 1R01 CA175370)
5. Role of neuro-immune interaction in lymphocyte function (3SC1 CA182843-07S1) 6. Computational modeling of lymphocyte networks (SC1 CA182843)
Small-Molecule Natural Product Physachenolide C Potentiates Immunotherapy Efficacy by Targeting BET Proteins.
Tewary P, Brooks AD, Xu YM, Wijeratne EMK, Babyak AL, Back TC, Chari R, Evans CN, Henrich CJ, Meyer TJ, Edmondson EF, Prudente de Aquino MT, Kanagasabai T, Shanker A, Gunatilaka AAL, Sayers TJ
Phase II Study of Immunotherapy With Tecemotide and Bevacizumab After Chemoradiation in Patients With Unresectable Stage III Non-Squamous Non-Small-Cell Lung Cancer (NS-NSCLC): A Trial of the ECOG-ACRIN Cancer Research Group (E6508).
Patel JD, Lee JW, Carbone DP, Wagner H, Shanker A, de Aquino MTP, Horn L, Johnson ML, Gerber DE, Liu JJ, Das MS, Al-Nsour MA, Dakhil CSR, Ramalingam S, Schiller JH
Critical Neurotransmitters in the Neuroimmune Network.
Hodo TW, de Aquino MTP, Shimamoto A, Shanker A
Specific Targeting of Notch Ligand-Receptor Interactions to Modulate Immune Responses: A Review of Clinical and Preclinical Findings.
Goruganthu MUL, Shanker A, Dikov MM, Carbone DP
Editorial: Lymphocyte Functional Crosstalk and Regulation.
Srivastava RM, Marincola FM, Shanker A
CD8+ T Lymphocyte and NK Cell Network: Circuitry in the Cytotoxic Domain of Immunity.
Uzhachenko RV, Shanker A
Lymphocyte effector crosstalk in inflamed tumor microenvironment, Bioengineered agents for cancer immunotherapy, Immunoscore signature for cancer health disparity, neuro-immune interaction, Neuroimmunotherapy