Faculty Biography

Pius Nde, PhD

Associate Professor
Microbiology, Immunology, Physiology
School of Medicine
(615) 327-6997 | pnde@mmc.edu

Research Themes

Cardiovascular Disease, Gastrointestinal Diseases, Infectious Diseases

Active Research Projects

Molecular mechanisms of Trypanosoma cruzi cardiopathogenesis (NIH) Trypanosoma cruzi-based Therapy for aggressive Cancers (Meharry Medical College)

Goals Schematic

Suman et al.


Thrombospondin-1 Plays an Essential Role in Yes-Associated Protein Nuclear Translocation during the Early Phase of Trypanosoma cruzi Infection in Heart Endothelial Cells.
Ashutosh Arun, Kayla J Rayford, Ayorinde Cooley, Girish Rachakonda, Fernando Villalta, Siddharth Pratap, Maria F Lima, Nader Sheibani, Pius N Nde

Phospho-proteomic analysis of primary human colon epithelial cells during the early Trypanosoma cruzi infection phase.
Shankar Suman, Girish Rachakonda, Sammed N Mandape, Shruti S Sakhare, Fernando Villalta, Siddharth Pratap, Maria F Lima, Pius N Nde

Epitope Capsid-Incorporation: New Effective Approach for Vaccine Development for Chagas Disease.
Qiana L Matthews, Anitra L Farrow, Girish Rachakonda, Linlin Gu, Pius Nde, Alexandre Krendelchtchikov, Siddharth Pratap, Shruti S Sakhare, Steffanie Sabbaj, Maria F Lima, Fernando Villalta

Early Regulation of Profibrotic Genes in Primary Human Cardiac Myocytes by Trypanosoma cruzi.
Aniekanabassi N Udoko, Candice A Johnson, Andrey Dykan, Girish Rachakonda, Fernando Villalta, Sammed N Mandape, Maria F Lima, Siddharth Pratap, Pius N Nde

VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis.
Galina I Lepesheva, Tatiana Y Hargrove, Girish Rachakonda, Zdzislaw Wawrzak, Sébastien Pomel, Sandrine Cojean, Pius N Nde, W David Nes, Charles W Locuson, M Wade Calcutt, Michael R Waterman, J Scott Daniels, Philippe M Loiseau, Fernando Villalta

Immunization with Hexon modified adenoviral vectors integrated with gp83 epitope provides protection against Trypanosoma cruzi infection.
Anitra L Farrow, Girish Rachakonda, Linlin Gu, Valentina Krendelchtchikova, Pius N Nde, Siddharth Pratap, Maria F Lima, Fernando Villalta, Qiana L Matthews


Trypanosoma cruzi, megacolon, cardiac fibrosis, fibrotic genes, gene network architecture